NGS Library Preparation Market: Expanding Horizons of Next-Generation Sequencing
According to a new market research report
titled, ‘NGS Library Preparation Market By Product
(Kits, Reagents, Instruments), Sequencing Type (Genome, Exome, Targeted),
Application (Diagnostics, Discovery), End User (Hospitals, Diagnostic
Laboratories, Pharmaceutical, Academic) - Global Forecast to 2030,’ published
by Meticulous Research®, the NGS library preparation market is projected to reach
$6.47 billion by 2030, at a CAGR of 16.0% from 2023 to 2030.
Next-generation sequencing (NGS) enables parallel sequencing of millions
of small DNA fragments for low per-base costs in a short time. It provides
information about the composition of complex DNA samples and is used for almost
all genomic applications. The library preparation is the first step of the next
generation sequencing in which the nucleic acid material is converted into
standard libraries suitable for loading onto a sequencing instrument. In a typical
NGS library preparation protocol, libraries are created by fragmenting DNA and
adding specialized adapters to both ends. Many companies offer kits &
reagents for this process.
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The declining costs of sequencing, the increasing prevalence of cancer
and genetic disorders, the growing utilization of NGS in disease diagnostics
and precision medicine, and rising R&D investments and healthcare
expenditures are the key factors driving the growth of the NGS library preparation
market. Furthermore, the increasing applications of next-generation sequencing
technology and collaborations between vendors to develop automated library
preparation protocols are expected to create market growth opportunities.
However, availability of alternative technologies and the low chances of
identifying positive actionable mutations for precision medicine are a
restraining factor for the market’s growth. Additionally, regulatory and
standardization concerns in diagnostic testing and the limited expertise and
sequencing capabilities of small & mid-sized laboratories are major
challenges for market growth.
Growing
Automation to offer Significant opportunities for NGS Library Preparation
Market
Library preparation activities such as DNA extraction, quantification,
fragmentation, normalization, purification, and quality control are
labor-intensive and slow down the generation of sequencing data. Although most
procedures are carried out with the use of a kit, creating a library for whole
genome sequencing takes time and effort.
The automation of NGS library preparation increases process efficiency
and generates more consistent and reproducible results. It also helps reduce
turnaround times, despite expanding sample workloads. With the increasing application
of NGS in various fields, manual NGS library preparation is considered a highly
labor-intensive task. Automating NGS library preparation helps researchers
improve their library quality and achieve consistent yields, enabling the
generation of reliable and reproducible NGS data. It also enhances efficiency
in terms of time and cost. The risk of contamination is greatly reduced by
reducing human interactions with the reagents and samples.
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Companies are collaborating to create methods for automating NGS library
preparation. Thus, the automation of NGS library preparation is expected to
streamline NGS workflow and offer significant growth opportunities for the NGS
library preparation market.
The NGS library preparation market is segmented by Product [Reagents
& Consumables (DNA Library Preparation and RNA Library Preparation), and
Instruments/Workstations], by Application [Research and Other Applications
(Drug Discovery, Agriculture & Animal Research, Other Applications), Clinical
Applications (Reproductive Health, Oncology, Infectious Diseases, Other
Clinical Applications)], by Sequencing Type (Targeted Genome Sequencing, Whole
Genome Sequencing, Whole Exome Sequencing, and Other Sequencing Types), End
User (Pharmaceutical & Biotechnology Companies, Hospitals & Diagnostic
Laboratories, Academic & Research Centres, and Other End Users), and
Geography. The study also evaluates industry competitors and analyzes their
market shares at the global and regional levels.
Based on product, in 2023, the reagents & consumables segment is
expected to account for the larger share of the NGS library preparation market.
The large market share of this segment is attributed to the recurrent
requirement of reagents & consumables of the NGS library preparation
process, increased demand for automated NGS library preparation kits, and
increased penetration of NGS for genomic analysis.
Based on application, in 2023, the research & other applications
segment is expected to account for the largest share of the NGS library
preparation market. NGS is recently being widely used as an essential genomics
tool for plant and animal breeding and improvement programs. The large market
share of this segment is attributed to the increasing demand of NGS in
agriculture & animal research, increasing demand for sequencing procedures
in animal and plant breeding, growing demand of NGS in food research and
microbiology studies, and increasing research programs for personalized
medicines.
Based on sequencing type, in 2023, the targeted sequencing segment is
expected to account for the largest share of the NGS library preparation
market. Targeted sequencing is a rapid and cost-effective method to detect known
and novel variants in selected genes. The large market share of this segment is
attributed to factors such as increased applications in identifying primary
immunodeficiencies and specific gene-associated diseases.
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Based on end user, in 2023, the pharmaceutical & biotechnology
companies segment is expected to account for the largest share of the NGS
library preparation market.. The growth of this segment is attributed to
decreasing costs of NGS systems, development of companion diagnostics and
precision medicine, increased utilization of NGS technology for biomarker
discovery, and increased drug delivery applications using NGS systems.
Based on geography, the NGS library preparation market is segmented into
North America, Europe, Asia-Pacific, Latin America, and the Middle East &
Africa, with a further analysis of major countries in these regions. In 2023,
North America is expected to account for the largest share of the NGS library
preparation market, followed by Europe, Asia-Pacific, Latin America, and the
Middle East & Africa. However, Asia-Pacific is projected to be the
fastest-growing region of the global NGS library preparation market. The fast growth
in this region is attributed to the increasing penetration of NGS for various
clinical applications in countries like China, Japan, and Singapore, the
improving healthcare infrastructure, high patient population with various
genetic diseases, and growing investments in the region.
The report includes a competitive landscape based on an extensive
assessment of the geographic presence and key strategic developments of leading
market players during 2020–2022. The NGS library preparation market has
witnessed several new product launches, approvals, partnerships &
agreements, and acquisitions in recent years.
The key players dominating the NGS library preparation market are
Illumina, Inc. (U.S.), Thermo Fisher Scientific Inc. (U.S.), QIAGEN N.V.
(Germany), Agilent Technologies, Inc. (U.S.), Danaher Corporation (U.S.),
Pacific Biosciences of California, Inc. (U.S.), PerkinElmer Inc. (U.S.), F.
Hoffmann-La Roche AG (Switzerland), New England Biolabs, Inc. (U.S.), Tecan
Group Ltd. (Switzerland), Merck KGaA (Germany), Diagenode S.A. (Belgium)
(Subsidiary of Hologic, Inc. (U.S.)), and Beijing Genomics Institute (BGI)
(China).
To gain more
insights into the market with a detailed table of content and figures, click
here: https://www.meticulousresearch.com/product/ngs-library-preparation-market-5319
Scope of the Report:
NGS Library Preparation Market, by Product
- Reagents
& Consumables
- DNA
Library Preparation
- RNA
Library Preparation
- Instruments
& Workstations
NGS Library Preparation Market, by Application
- Research
and Other Applications
- Drug
Discovery
- Agriculture
& Animal Research
- Other
Applications
Note: Other applications include basic research
(genomics, molecular biology, and other life sciences), and forensics &
food microbiology.
- Clinical
Application
- Reproductive
Health
- Oncology
- Infectious
Disease
- Other
Clinical Applications
Note: Other clinical applications include
applications in detection aberrations in neurological disorders, rare diseases,
metabolic and immune disorders, and food-borne illnesses.
NGS Library Preparation Market, by Sequencing Type
- Targeted
Genome Sequencing
- Whole
Genome Sequencing
- Whole
Exome Sequencing
- Other
Sequencing Types
Note: Other Sequencing types
include degradome sequencing, chromatin immunoprecipitation (ChIP) sequencing,
and methylation sequencing
NGS Library Preparation Market, by End User
- Pharmaceutical
& Biotechnology Companies
- Hospitals
& Diagnostic Laboratories
- Academic
Institutes & Research Centres
- Others
End Users
Note: Other end users
include forensic laboratories & security agencies, the food industry, and
the agriculture industry
NGS Library Preparation Market, by Geography
- North
America
- U.S.
- Canada
- Europe
- Germany
- France
- U.K.
- Italy
- Spain
- Rest
of Europe (RoE)
- Asia-Pacific
- China
- Japan
- India
- Rest
of Asia-Pacific (RoAPAC)
- Latin
America
- Middle
East & Africa
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